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Fibrous dysplasia is a chronic disorder in which bone expands due to abnormal development of fibrous tissue, often resulting in one, or more, of the following:
Any bone can be affected. More than one bone can be affected at any one time, and, when multiple bones are affected, it is not unusual for them to all be on one side of the body. However, fibrous dysplasia does not spread from one bone to another. The most commonly affected bones include the following:
Some people develop hormonal problems and a condition called McCune-Albright syndrome. McCune-Albright syndrome, another form of fibrous dysplasia, includes different symptoms, such as early onset of puberty and skin spots, called café-au-lait spots.
Fibrous dysplasia usually occurs in children ages 3 to 15, but it sometimes is not diagnosed until adulthood. It is found equally between males and females.
The exact cause of fibrous dysplasia is not known, but it is believed to be due to a chemical irregularity in a specific bone protein. This bone protein abnormality may be due to a gene mutation present at birth, but it is not known to be an inherited disorder.
The following are the most common symptoms for fibrous dysplasia. However, each individual may experience symptoms differently. Symptoms may include:
The symptoms of fibrous dysplasia may resemble other bone disorders or medical problems. Always consult your physician for a diagnosis.
In addition to a complete medical history and physical examination, diagnostic procedures for fibrous dysplasia may include the following:
Specific treatment for fibrous dysplasia will be determined by your physician based on:
Treatment may include: