Neonatal Research Institute
Clinical Trial: Sustained Inflation in the Delivery Room
Clinical trial: The acute physiological changes with sustained inflation in the delivery room (SI-DR trial)
Primary investigator: Dr. Anup Katheria
About this trial.
Immaturity makes the transition from intrauterine life to extrauterine life more difficult. During this transition — termed the "Golden Hour" — the newborn must generate the critical opening pressure to aerate her lungs, remove the large volume of liquid and fill the lung with air to enable extrauterine life. Performing this well in the delivery room (DR) provides the best start to the critical first days of life. Yet the best manner to achieve this is poorly studied. We compare two such methods.
Sustained inflation is being studied in a large multicenter trial sponsored by the National Institute of Health, in which Sharp is participating. As a substudy of this trial, we will look at the actual physiologic effects of such an inflation on heart rate and breathing.
Our hypothesis is that giving a single prolonged inflation will:
- Have a more rapid increase in heart rate to normal levels
- Open up and maintain the baby's lung inflation better
- Take larger and more effective spontaneous breaths
To learn more about the NICU at Sharp Mary Birch, visit Neonatal Intensive Care Unit. For more information about the NRI or to learn more about our clinical trials, send us an email or call 858-939-4112.