Clinical Trial: Early Caffeine

Neonatal Research Institute

Premature infants are at risk of having pauses in breathing, or apneas, due to their immaturity. Premature infants are routinely given caffeine, a respiratory stimulant to prevent apneas and improve long-term development.

Clinical Trial
The effects of early caffeine on the need for ventilation and cardiac support in preterm neonates trial.

Primary Investigator
Dr. Anup Katheria

Research Coordinators
Kathy Arnell
Deborah Petruzzelli
Wade Rich

About This Trial
Many babies are given caffeine after the first day of life. We believe that giving caffeine in the first hours of life could help these babies breathe enough that they could avoid receiving a breathing tube and going on a ventilator.

Going on a ventilator and having a breathing tube is not good for the lungs. Also, giving caffeine earlier could help the heart function better and prevent low blood pressure, which affects many premature babies.

Our hypothesis is that giving caffeine will:

  • Decrease damage to babies' lungs
  • Improve babies' blood pressure so they don't need blood pressure medicine
  • Improve babies' long-term neurological outcome
  • Prevent babies from needing a breathing tube and going on a ventilator

To learn more about this study, visit

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For More Neonatal Research Institute Clinical Trials Information
To learn more about the NICU at Sharp Mary Birch, visit Neonatal Intensive Care Unit at Sharp Mary Birch Hospital. For more information about the NRI or to learn more about our clinical trials, send us an email or call 858-939-4175.