Scientists Create Autism-Like Traits in Mice

Gene manipulation produces common behaviors and provides model for testing drugs, expert says

MONDAY, March 21 (HealthDay News) -- Scientists report that mutating a single gene produced mice with two of the most common autism traits, a finding they say could one day lead to the development of drugs to treat autism.

Currently, there are no effective drugs to treat the disorder.

Mutating the shank3 gene led to compulsive repetitive behavior and avoidance of social interaction in the mice, apparently caused by impaired communication between brain cells, said the researchers at Duke University and the McGovern Institute for Brain Research at the Massachusetts Institute of Technology.

The shank3 gene has been implicated in human autism.

The study was published online March 20 in Nature.

"We now have a very robust model with a known cause for autistic-like behaviors," senior author Guoping Feng, a professor of brain and cognitive sciences at MIT, said in a McGovern Institute news release. "We can figure out the neural circuits responsible for these behaviors, which could lead to novel targets for treatment."

The genetically altered mice also provide a way to assess experimental autism drugs before they're tested in humans.

Scientists acknowledge that research involving animals often fails to result in beneficial treatments for humans.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about autism.

Robert Preidt SOURCE: McGovern Institute for Brain Research, news release, March 20, 2011

Related Articles

Learn More About Sharp
Sharp HealthCare is San Diego's health care leader with seven hospitals, two medical groups and a health plan. Learn more about our San Diego hospitals, choose a Sharp-affiliated San Diego doctor or browse our comprehensive medical services.

Health News is provided as a service to Sharp Web site users by HealthDay. Sharp HealthCare nor its employees, agents, or contractors, review, control, or take responsibility for the content of these articles. Please read the Terms of Use for more information.