Neonatal Research Institute
Research Developments and Published Studies of the Neonatal Research Institute
Learn about our recent research developments at the Neonatal Research Institute (NRI):
- The Thrasher Research Fund approved a grant in support of the NRI's NIH-funded PREMOD2 study. The $531,788 grant will be used over three years to support the follow-up efforts of the NRI and its domestic and international partner sites. These efforts will serve babies enrolled in PREMOD2 and ensure their social and cognitive development is on track and they are prepared for success in kindergarten and beyond.
- Sharp Mary Birch received a $5 million donation from the Alexander and Eva Nemeth Foundation to help fund two programs that give at-risk infants a healthier start in life
- The NRI received a $3.1 million research project grant from the National Institutes of Health (NIH), making this our fourth grant from this prestigious body
- In the spring of 2017 the Eunice Kennedy Shriver National Institute of Child Health and Human Development, an institute of the NIH, awarded Sharp Mary Birch Hospital for Women & Newborns a $2.9 million R01 grant to carry out a multicenter, multinational trial of 1,500 babies to determine if umbilical cord milking is as good as or better than delayed umbilical cord clamping in premature infants.
- The Gerber Foundation awarded the NRI $200,000 to conduct the first study to characterize normal brain function of premature infants during the first 72 hours of life. This is an observational study to evaluate brain perfusion and function using Near Infrared Spectroscopy (NIRS), a monitor that allows us to look at oxygen in the tissue of the brain, and limited EEG monitoring.
- The Thrasher Fund awarded the NRI $175,000 to assess neurodevelopmental follow up of infants in the PREMOD trial at two years of age.
- The Hartwell Foundation provided funding to conduct a trial in term infants to determine if early placement of EEG electrodes and brain oxygen monitoring will allow for early detection of serious poor outcomes. We are constantly searching for ways in which to decrease long-term problems in premature infants, and this study will increase our understanding of newborns' brain function after birth.
- The NIH awarded the NRI a grant of $354,750 to study whether delayed cord clamping can improve long-term brain function for babies needing resuscitation at birth. The study is made possible in part by revolutionary newborn resuscitation beds at Sharp Mary Birch, which allow for delayed cord clamping during newborn resuscitation.
- The Little Giraffe Foundation and Tarsadia Foundation awarded neonatal research grants for more than $10,000 in support of a study on the respiratory effects of caffeine administered to preterm babies shortly after birth in order to prevent intubation in the first hours of life.
- The NRI was a recipient of a grant, totaling $41,264, from the Will Rogers Institute 2014 Neonatal Ventilator and Pulmonary Grant Program in support of neonatal pulmonary equipment
The following articles highlight studies done at our Neonatal Research Institute:
- Comparative Effectiveness of Drugs Used to Constrict the Patent Ductus Arteriosus: A Secondary Analysis of the PDA-TOLERATE Trial - Journal of Perinatology, March 8, 2019
- Effect of Sustained Inflations vs. Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants: The SAIL Randomized Clinical Trial - JAMA, March 2019
- PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age - The Journal of Pediatrics, Oct. 16, 2018
- Umbilical Cord Milking: A Review - Frontiers in Pediatrics, Nov. 13, 2018
- Maternal Bleeding Complications Following Early Versus Delayed Umbilical Cord Clamping in Multiple Pregnancies - BMC Pregnancy and Childbirth, 2018
- Impact of a Neuro-Intensive Care Service for Newborns - Journal of Neonatal-Perinatal Medicine, 2018
- A New Wrinkle: Umbilical Cord Management (How, When, Who) - Seminars in Fetal and Neonatal Medicine, 2018
- Early Prediction of a Significant Patent Ductus Arteriosus in Infants <32 Weeks Gestational Age - Journal of Neonatal-Perinatal Medicine, 2018
- Functional Echocardiography in the Neonatal Intensive Care Unit - Indian Pediatrics, May 2018
- Incidence of Hypocapnia, Hypercapnia, and Acidosis and the Associated Risk of Adverse Events in Preterm Neonates - Respiratory Care, August 2018
- Acceptability of Bedside Resuscitation With Intact Umbilical Cord to Clinicians and Patients' Families in the United States - Frontiers in Pediatrics, April 2018
- The Neu-Prem Trial: Neuromonitoring of Brains of Infants Born Preterm During resuscitation - a Prospective Observational Cohort Study - The Journal of Pediatrics, April 2018
- Incidence of Hypocapnia, Hypercapnia, and Acidosis and the Associated Risk of Adverse Events in Preterm Neonates - Respiratory Care, April 2018
- Advances in Diagnosis and Management of Hemodynamic Instability in Neonatal Shock - Frontiers in Pediatrics, January 2018
- A Randomized Clinical Trial of Umbilical Cord Milking vs. Delayed Cord Clamping in Preterm Infants: Neurodevelopmental Outcomes at 22-26 Months of Corrected Age - The Journal of Pediatrics, December 2017
- NEC-zero Recommendations From Scoping Review of Evidence to Prevent and Foster Timely Recognition of Necrotizing Enterocolitis - Maternal Health, Neonatology, and Perinatology, 2017
- Evaluation of the Safety of Drugs and Biological Products Used During Lactation: Workshop Summary - Clinical Pharmacology & Therapeutics, June 2017
- Waiver of Consent in a Trial Intervention Occurring at Birth - How Do Parents Feel? - Frontiers in Pediatrics, 2017
- Hemodynamic Effects of Sodium Bicarbonate Administration - Journal of Perinatology, 2017
- Providing a Placental Transfusion in Newborns Who Need Resuscitation - Frontiers in Pediatrics, 2017
- Placental Transfusion: A Review - Journal of Perinatology, September 2016
- Resistance of Colorimetric Carbon Dioxide Detectors Commonly Utilized in Neonates - Respiratory Care, August 2016
- Neonatal Resuscitation With an Intact Cord: A Randomized Clinical Trial - Journal of Pediatrics, August 2016
- The 30 Second Rule: The Effects of Prolonged Intubation Attempts on Oxygen Saturation and Heart Rate in Preterm Infants in the Delivery Room - Minerva Pediatrica, April 2016
- Optimizing Care of the Preterm Infant Starting in the Delivery Room - American Journal of Perinatology, February 2016
- Relationship Between Near-Infrared Spectroscopy and Transabdominal Ultrasonography: Noninvasive Monitoring of Intestinal Function in Neonates - Medical Science Monitor, January 2016
- Umbilical Cord Milking Versus Delayed Cord Clamping in Preterm Infants - Pediatrics, June 2015
- Measuring Cardiac Changes Using Electrical Impedance During Delayed Cord Clamping: A Feasibility Trial - Maternal Health, Neonatology and Perinatology, June 2015
- A Pilot Randomized Controlled Trial of Early Versus Routine Caffeine in Extremely Premature Infants - American Journal of Perinatology, January 2015
- Postnatal Systemic Blood Flow in Neonates With Abnormal Fetal Umbilical Artery Doppler - Obstetrics and Gynecology, March 2014
- The Use of Electrical Cardiometry for Continuous Cardiac Output Monitoring in Preterm Neonates: A Validation Study - American Journal of Perinatology, December 2014
- The Effects of Umbilical Cord Milking on Hemodynamics and Neonatal Outcomes in Premature Neonates - Journal of Pediatrics, May 2014
- Umbilical Cord Milking Improves Transition in Premature Infants at Birth - PLoS One, April 2014
Learn about presentations given by the NRI team at various conferences:
Held in March 2017, the conference featured expert international speakers presenting clinical research and current practices in neonatal resuscitation, or help with breathing at birth. Dr. Anup Katheria, director of the Neonatal Research Institute, discussed how resuscitation interventions are possible to perform close enough to mother to keep the umbilical cord intact by the use of a specialized resuscitation bed, and the ongoing research that delayed cord clamping improves blood pressure and brain oxygenation in an infant at risk for resuscitation.