Wegovy in pill form: A new way to support weight loss
In combination with a healthy lifestyle, the new Wegovy semaglutide pill can be an effective tool for chronic weight management.
You’ve likely seen the ads and social media posts about weight loss pills, patches and shots — many claiming to include GLP-1 medications and all professing to be the solution to losing extra pounds. The big question is, which is the best choice?
Dr. Neelima Chu, an endocrinologist with Sharp Rees-Stealy Medical Group, breaks down your weight loss options:
How does a GLP-1 shot work in comparison to weight loss pills or patches?
To start, GLP-1 injections containing semaglutide — often known by the generic term “Ozempic” — are FDA-approved medications that directly activate GLP-1 receptors in the body, helping regulate appetite, blood sugar and digestion. They work by helping people feel full sooner and for a longer period. When used at the recommended dose and combined with lifestyle changes, they can lead to significant weight loss and improved health.
In addition to injectables, the FDA recently approved a Wegovy® pill. Studies suggest weight loss from the Wegovy® pill is similar to that experienced with the brand's injectable form.
Patches and non-Wegovy® pills, marketed for weight loss, are not yet FDA-regulated. Ingredients, dosages and effectiveness in them can vary widely depending on the brand. Some contain natural ingredients, such as berberine, pomegranate extract, cinnamon, and L-glutamine. This mix has been shown to improve insulin sensitivity and sleep and reduce stress. However, the scientific evidence supporting their role in weight loss is limited.
Do they all offer the same weight loss results?
The shots, patches and pills do not produce the same results. GLP-1 shots and the Wegovy® pill are clinically proven to be the most effective option for weight loss and blood sugar control.
Alternatively, the non-Wegovy® pills and patches typically contain natural supplements rather than active GLP-1 medications. They are not substitutes for prescription GLP-1 therapies.
However, not everyone can tolerate the side effects of the shots. These can include nausea, acid reflux, constipation or diarrhea, and rarely, a type of thyroid cancer called medullary thyroid cancer.
Are the doses the same in a shot, pill or patch?
GLP-1 injections and the Wegovy® pill contain a precisely measured, FDA-approved dose. The pills and patches marketed as supplements do not contain the same active ingredient. As a result, the exact dosage and potency of their ingredients are often unknown and inconsistent.
Which medication should I choose?
Doctors typically recommend GLP-1 shots or the Wegovy® pill for weight loss because they have undergone clinical trials, and evidence supports their safety and effectiveness. The decision about which weight loss option is appropriate should always be made in partnership with your doctor, who will consider several important factors, including:
Your overall health
Medical history
Current medications
The amount of weight you’re aiming to lose
Your tolerance for certain treatments
Always talk with your doctor when exploring effective weight loss options. These may include nutritional counseling, exercise programs, behavioral support and FDA-approved medications like GLP-1 injections or the Wegovy® pill. This personalized approach ensures that your weight loss plan is both safe and sustainable.
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